Selective destruction of nigrostriatal dopaminergic neurons does not alter [3H]-ryanodine binding in rat striatum
Braz. j. med. biol. res
;
33(2): 237-40, Feb. 2000. tab
Artigo
em Inglês
| LILACS
| ID: lil-252301
RESUMO
Dopamine nigrostriatal neurons are important for motor control and may contain a particularly dense population of ryanodine receptors involved in the control of dopamine release. To test this hypothesis, we used a classical model of unilateral selective lesion of these neurons in rats based on 6-hydroxydopamine (6-OHDA) injection into the substantia nigra. Binding of [3H]-GBR 12935, used as a presynaptic marker since it labels specifically the dopamine uptake complex, was dramatically decreased by 83-100 percent in striatum homogenates after 6-OHDA lesion. On the contrary, no reduction of [3H]-ryanodine binding was observed. The present data indicate that [3H]-ryanodine binding sites present in rat striatum are not preferentially localized in dopaminergic terminals
Texto completo:
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Índice:
LILACS (Américas)
Assunto principal:
Dopamina
/
Oxidopamina
/
Adrenérgicos
/
Canal de Liberação de Cálcio do Receptor de Rianodina
/
Corpo Estriado
/
Síndrome Maligna Neuroléptica
/
Neurônios
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2000
Tipo de documento:
Artigo
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