Partículas lipoproteicas LpA-I, LpA-I: A-II y LpB en enfermedad coronaria / Lipoprotein particles LpA-I, LpA-I: A-II and LpB in patients with coronary artery disease
Rev. méd. Chile
;
128(1): 9-16, ene. 2000. tab, graf
Artigo
em Espanhol
| LILACS
| ID: lil-258082
ABSTRACT
Background:
High density lipoproteins are an heterogeneous population of particles. Two main subpopulations have been identified, one contains Apo A-I and Apo A-II and is denominated LpA-IA-II and another one contains only Apo A-I and is denominated LpA-I.Aim:
To measure the concentrations of these particles in patients with stable coronary artery disease. Patients andMethods:
Serum lipids, A-I and B apolipoproteins, LpA-I, LpA-IA-II and LpB particles were measured in 73 men aged 33 to 82 years with angiographically documented coronary artery disease (CAD) and 33 control subjects aged 39 to 76 years. LpA-I, LpA-IA-II and LpB were measured by a noncompetitive enzyme linked immunoassay using previously characterized monoclonal antibodies against ApoA-I, ApoA-II and apoB.Results:
Patients with CAD had significantly higher mean levels of LDL cholesterol than the control group (p= 0.038). The mean concentration of LpA-I particles in patients with CAD was significantly lower (p= 0.031) than in control subjects, while the concentration of LpA-IA-II particles was significantly higher (p=0.016). The percentage of coronary stenosis correlated negatively with LpA-I and positively with LpA-IA-II. The best relative risk (RR) indicator in these patients was LDL-cholesterol. The relative risk increases 2.5 fold when LpA-I falls below the cut-off level. Likewise, the relative risk increases 3-fold when LpA-IA-II raises over the cut-off level.Conclusions:
Our findings indicate that the quantification of LpA-I and LpA-IA-II particles might allow a more accurate evaluation of the CAD risk than HDL cholesterol. LpA-I might represent the antiatherogenic fraction of HDL
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Doença das Coronárias
/
Lipoproteínas
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2000
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
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