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Intoxicación aguda con metotrexato usado con fines abortivos: descripión de 2 casos / Acute intoxication with methotrexate, used as an abortive: report of two cases
Alfaro Lucero, Jorge; Von Muhlenbrock S., Ricardo; Burgos S., Nelson; Valdés R., Enrique; Gana A., Clara; Conte L., Guillermo; Araos H., Daniel; Plate B., Ludwig.
  • Alfaro Lucero, Jorge; Universidad de Chile. Hospital Clínico. Departamento de Medicina Interna.
  • Von Muhlenbrock S., Ricardo; s.af
  • Burgos S., Nelson; s.af
  • Valdés R., Enrique; s.af
  • Gana A., Clara; s.af
  • Conte L., Guillermo; s.af
  • Araos H., Daniel; s.af
  • Plate B., Ludwig; s.af
Rev. méd. Chile ; 128(3): 315-8, mar. 2000.
Artigo em Espanhol | LILACS | ID: lil-260191
RESUMO
Acute intoxication with methotrexate, used as an abortive, has not been described in Chile. We report two female patients, aged 15 and 24 years old, who presented with mucositis, erythrodermia, pancytopenia, and elevation of hepatic enzymes. Plasma methotrexate levels confirmed the clinical diagnosis and both patients were treated with high leucovorin doses and management of associated complications. In one patient, pregnancy continued, giving birth to a newborn with cranial, face and limb malformations. The second patient had a late rescue with leucovorin and was discharged with a persistent sensory motor neuropathy. Considering the severity of complications and that patients may deny its use, when there is reasonable clinical suspicion of methotrexate intoxication, leucovorin treatment should be started
Assuntos
Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Intoxicação / Metotrexato / Leucovorina Limite: Adolescente / Adulto / Feminino / Humanos / Gravidez Idioma: Espanhol Revista: Rev. méd. Chile Assunto da revista: Medicina Ano de publicação: 2000 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Intoxicação / Metotrexato / Leucovorina Limite: Adolescente / Adulto / Feminino / Humanos / Gravidez Idioma: Espanhol Revista: Rev. méd. Chile Assunto da revista: Medicina Ano de publicação: 2000 Tipo de documento: Artigo