Receptores activadores de la proliferación peroxisomal / Activated receptors of the peroximonal proliferation

RESUMO

Peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors that belong to the steroid/retinoic acid receptor superfamily. All their characterized target genes encode proteins that participate in lipid homeostasis. The finding that antidiabetic thiazolidinediones and adipogenic prostanoids are ligans of one of the PPARS reveals a novel signaling pathway that directly links these compounds to processes involved in glucose homeostasis and lipid metabolism including adipocyte differentiation. An understanding of this pathway could designate PPARs as targets for the development and efficient treatments for several metabolic disorders