Hair cell loss and regeneration in the chick cochlea after treatment with gentamicin
Acta physiol. pharmacol. ther. latinoam
;
49(4): 204-9, 1999. ilus
Artigo
em Inglês
| LILACS
| ID: lil-260726
ABSTRACT
Hair cells can be damaged by countless agents, among them aminoglycoside antibiotics. In the cheek cochlea, the hair cell loss can be recovered by regeneration. The objectives of the present investigation were to estudy the time progression of injury caused by gentamicin and the regeneration process in chick hair cells. Gentamicin was administered in a single subcutaneous dose of 125 or 250 mg/kg to two groups of 3-day old chicks. The cochleae were processed for analysis by scanning electron microscopy on the 1st, 3rd, 5th and 20th day after injection The cellular sequence of degeneration and regeneration was studied. On the 20th day, most it he damaged cochlear area showed regenerated hair and suport cells. Stereocilia and microvilli were observed on the apical surface of the regenerated hair cells.
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Índice:
LILACS (Américas)
Assunto principal:
Regeneração
/
Gentamicinas
/
Células Ciliadas Auditivas
/
Antibacterianos
Limite:
Animais
Idioma:
Inglês
Revista:
Acta physiol. pharmacol. ther. latinoam
Assunto da revista:
Farmacologia
/
Fisiologia
/
Terapêutica
Ano de publicação:
1999
Tipo de documento:
Artigo
/
Congresso e conferência
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