Great amount of C.pneumoniae in rupture plaque vessel segments at autopsy: a comparative study with stable plaques
Arq. bras. cardiol
;
74(2): 149-51, Jan. 2000. ilus
Artigo
em Inglês
| LILACS
| ID: lil-262348
ABSTRACT
A possible relationship between C.pneumoniae (CP) infection, atherosclerosis and acute myocardial infarction is a debated matter. Now we performed the search of CP in histological segments of fatal ruptured plaques and of stable plaques by histochemistry (Macchiavello stain), immunohistochemistry and in situ hybridization techniques. Electron microscopy and confocal laser microscopy techniques were used in two additional cases. The semi-quantitification of CP + cells (0-4+) and quantification of lymphocytes demonstrated greater amount of CP + cells and more inflammation in the adventitia of vulnerable plaque vessel segments than of stable ones, larger amount of CP + cells in adventitia than in the plaque and high frequency of CP + cells in all groups studied. This preliminary study strongly suggests a direct pathogenetic involvement of adventitial CP in the rupture of the atheromatous plaque, development of acute myocardial infarction and also in the development of atherosclerosis.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Infecções por Chlamydia
/
Chlamydophila pneumoniae
/
Aterosclerose
/
Infarto do Miocárdio
Limite:
Humanos
Idioma:
Inglês
Revista:
Arq. bras. cardiol
Assunto da revista:
Cardiologia
Ano de publicação:
2000
Tipo de documento:
Artigo
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