Genomic rearrangements in trypanosomatids: an alternative to the "One Gene" evolutionary hypothesis?
Mem. Inst. Oswaldo Cruz
;
95(4): 527-34, July-Aug. 2000.
Artigo
em Inglês
| LILACS
| ID: lil-264232
RESUMO
Most molecular trees of trypanosomatids are based on point mutations within DNA sequences. In contrast, there are very few evolutionary studies considering DNA (re) arrangement as genetic characters. Waiting for the completion of the various parasite genome projects, first information may already be obtained from chromosome size-polymorphism, using the appropriate algorithms for data processing. Three illustrative models are presented here. First, the case of Leishmania (Viannia) braziliensis/L. (V.) peruviana is described. Thanks to a fast evolution rate (due essentially to amplification/deletion of tandemly repeated genes), molecular karyotyping seems particularly appropriate for studying recent evolutionary divergence, including eco-geographical diversification. Secondly, karyotype evolution is considered at the level of whole genus Leishmania. Despite the fast chromosome evolution rate, there is qualitative congruence with MLEE- and RAPD-based evolutionary hypotheses. Significant differences may be observed between major lineages, likely corresponding to major and less frequent rearrangements (fusion/fission, translocation). Thirdly, comparison is made with Trypanosoma cruzi. Again congruence is observed with other hypotheses and major lineages are delineated by significant chromosome rearrangements.
Texto completo:
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Índice:
LILACS (Américas)
Assunto principal:
Rearranjo Gênico
/
Cromossomos
/
Trypanosomatina
/
Genoma de Protozoário
/
Evolução Molecular
Tipo de estudo:
Pesquisa qualitativa
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2000
Tipo de documento:
Artigo
País de afiliação:
Federação Russa
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