Effects of depot medroxyprogesterone acetate on the calcium metabolism of adult ovariectomized rats
Medicina (B.Aires)
;
60(4): 482-6, 2000. tab
Artigo
em Inglês
| LILACS
| ID: lil-273474
ABSTRACT
This paper describes experiments designed to test the effect of depot medroxyprogesterone acetate (DMPA) on calcium metabolism of adult ovariectomized rats. The 24 animals were randomly assigned to control or treated groups. Treated rats received 15 mg of DMPA i.m. per week, during four or twelve weeks. Controls received solvent alone. The variables characterizing the metabolism of Ca (daily rates of intestinal absorption and excretion, bone accretion and resorption and the sizes of the exchangeable pools and their rate constants) were measured with the aid of 45Ca according to Aubert and Milhaud. No effects were observed at four weeks of treatment. After twelve weeks, treatment produced serum levels of 46.5 ñ 5.6 nmoles of medroxyprogesterone/L, reduction of bone turnover (Ca accretion and resorption rates) and of the size of the slow exchanging Ca compartment. The increase in true Ca intestinal absorption was compensated by the increased endogenous fecal Ca excretion. The mass of body Ca was not affected by treatment.
Buscar no Google
Índice:
LILACS (Américas)
Assunto principal:
Progestinas
/
Ovariectomia
/
Cálcio
/
Acetato de Medroxiprogesterona
Limite:
Animais
Idioma:
Inglês
Revista:
Medicina (B.Aires)
Assunto da revista:
Medicina
Ano de publicação:
2000
Tipo de documento:
Artigo
País de afiliação:
Argentina
Instituição/País de afiliação:
Universidad Nacional de Rosario/AR
Similares
MEDLINE
...
LILACS
LIS