Double-blind clonazepam vs placebo in panic disorder treatment
Arq. neuropsiquiatr
;
58(4): 1025-9, Dec. 2000.
Artigo
em Inglês
| LILACS
| ID: lil-273842
ABSTRACT
OBJECTIVE:
To assess the effectiveness of clonazepam, in a fixed dose (2 mg/day), compared with placebo in the treatment of panic disorder patients.METHOD:
24 panic disorder patients with agoraphobia were randomly selected. The diagnosis was obtained using the structured clinical interview for DSM-IV . All twenty-four subjects were randomly assigned to either treatment with clonazepam (2 mg/day) or placebo, during 6 weeks. Efficacy assessments included change from baseline in the number of panic attacks; CGI scores for panic disorder; Hamilton rating scale for anxiety; and panic associated symptoms scale.RESULTS:
At the therapeutic endpoint, only one of 9 placebo patients (11.1 percent) were free of panic attacks, compared with 8 of 13 (61.5 percent) clonazepam patients (Fisher exact test; p=0,031).CONCLUSION:
the results provide evidence for the efficacy of clonazepam in panic disorder patients
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Transtorno de Pânico
/
Clonazepam
/
Moduladores GABAérgicos
/
Agorafobia
Tipo de estudo:
Ensaio Clínico Controlado
/
Pesquisa qualitativa
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Arq. neuropsiquiatr
Assunto da revista:
Neurologia
/
Psiquiatria
Ano de publicação:
2000
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Federal University of Rio de Janeiro/BR
Similares
MEDLINE
...
LILACS
LIS