Studies on the virulence and attenuation of Trypanosoma cruzi using immunodeficient animals
Mem. Inst. Oswaldo Cruz
;
95(supl.1): 175-8, 2000. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-274878
RESUMO
Tissue invasion and pathology by Trypanosoma cruzi result from an interaction between parasite virulence and host immunity. Successive in vivo generations of the parasite select populations with increasing ability to invade the host. Conversely, prolonged in vitro selection of the parasite produces attenuated sublines with low infectivity for mammals. One such subline (TCC clone) has been extensively used in our laboratory as experimental vaccine and tested in comparative experiments with its virulent ancestor (TUL). The experiments here reviewed aimed at the use of immunodeficient mice for testing the infectivity of TCC parasites. It has not been possible to obtain virulent, revertant sublines by prolonged passaged in such mice
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Trypanosoma cruzi
/
Hospedeiro Imunocomprometido
Tipo de estudo:
Estudo observacional
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2000
Tipo de documento:
Artigo
/
Congresso e conferência
País de afiliação:
Argentina
Instituição/País de afiliação:
Universidad Nacional de Salta/AR
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