Evaluación del compromiso retinal en diabéticos tipo 2 microalbuminúricos / Retinal involvement in type 2 diabetics with microalbuminuria
Rev. méd. Chile
;
128(10): 1085-92, oct. 2000. tab, graf
Artigo
em Espanhol
| LILACS
| ID: lil-277200
RESUMO
Background:
In patients with type 2 diabetes, the presence of microalbuminuria, reflecting a widespread vascular damage, can be a marker of nephropathy, retinophaty and cardiovascular diseases.Aim:
To study the relationship between microalbuminuria and the frequency, severity and outcome of retinopathy in patients with type 2 diabetes mellitus. Patients andmethods:
One hundred patients with type 2 diabetes were subjected to a clinical examination, serial monitoring of blood pressure and quarterly measurement of microalbuminuria by RIA. Annually, a fundoscopy, a color photography of the posterior pole and retinal angiofluorescence were performed. Retinophaty was classified as basal (mild to moderate), preproliferative and proliferative. Sixty four normoalbuminuric patients (urinary albumin of less than 30 mg/24 h) were included in group 1 and 36 patients with a urinary albumin over 30 mg/24 h in group 2. Fifty seven patients with normal blood pressure were randomly treated with enalapril or placebo and those with hypertension received enalapril or acebutolol to normalize blood pressure.Results:
Sixty one percent of group 1 patients and 41 percent of group 2 patients has retinopathy (p < 0.05). The retinal lesions were proliferative in 41 percent of group 2 patients and in 8 percent of group 1 patient (p < 0.05). Retinopathy was present in 67 percent of hypertensive patients of group 2 and in 41 percent of hypertensive patients of group 1. An unfavorable evolution of retinopathy was observed in 22 percent of group 2 patients and in 5 percent of group 1 patient (p < 0.05).Conclusions:
In type 2 diabetic patients, the presence of microalbuminuria is a prediction of a higher frequency, severity and dismal evolution of diabetic retinopathy
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Diabetes Mellitus Tipo 2
/
Retinopatia Diabética
/
Albuminúria
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2000
Tipo de documento:
Artigo
/
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