Catecholamine-induced vasoconstriction is sensitive to carbonic anhydrase I activation
Braz. j. med. biol. res
;
34(3): 339-345, Mar. 2001. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-281614
RESUMO
We studied the relationship between alpha- and beta-adrenergic agonists and the activity of carbonic anhydrase I and II in erythrocyte, clinical and vessel studies. Kinetic studies were performed. Adrenergic agonists increased erythrocyte carbonic anhydrase as follows adrenaline by 75 percent, noradrenaline by 68 percent, isoprenaline by 55 percent, and orciprenaline by 62 percent. The kinetic data indicated a non-competitive mechanism of action. In clinical studies carbonic anhydrase I from erythrocytes increased by 87 percent after noradrenaline administration, by 71 percent after orciprenaline and by 82 percent after isoprenaline. The increase in carbonic anhydrase I paralleled the increase in blood pressure. Similar results were obtained in vessel studies on piglet vascular smooth muscle. We believe that adrenergic agonists may have a dual mechanism of action the first one consists of a catecholamine action on its receptor with the formation of a stimulus-receptor complex. The second mechanism proposed completes the first one. By this second component of the mechanism, the same stimulus directly acts on the carbonic anhydrase I isozyme (that might be functionally coupled with adrenergic receptors), so that its activation ensures an adequate pH for stimulus-receptor coupling for signal transduction into the cell, resulting in vasoconstriction
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Vasoconstrição
/
Catecolaminas
/
Anidrases Carbônicas
/
Agonistas alfa-Adrenérgicos
/
Agonistas Adrenérgicos beta
Tipo de estudo:
Estudo diagnóstico
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2001
Tipo de documento:
Artigo
País de afiliação:
Alemanha
/
Romênia
/
Estados Unidos
Instituição/País de afiliação:
Faculty of Medicine/RO
/
Klinik Wilkenberg/DE
/
Medical Care Unit/US
/
Simleu Silvaniei/RO
Similares
MEDLINE
...
LILACS
LIS