Involvement of calcium in pain and antinociception
Braz. j. med. biol. res
;
34(4): 449-61, Apr. 2001. tab
Artigo
em Inglês
| LILACS
| ID: lil-282609
RESUMO
Calcium ions are widely recognized to play a fundamental role in the regulation of several biological processes. Transient changes in cytoplasmic calcium ion concentration represent a key step for neurotransmitter release and the modulation of cell membrane excitability. Evidence has accumulated for the involvement of calcium ions also in nociception and antinociception, including the analgesic effects produced by opioids. The combination of opioids with drugs able to interfere with calcium ion functions in neurons has been pointed out as a useful alternative for safer clinical pain management. Alternatively, drugs that reduce the flux of calcium ions into neurons have been indicated as analgesic alternatives to opioids. This article reviews the manners by which calcium ions penetrate cell membranes and the changes in these mechanisms caused by opioids and calcium antagonists regarding nociceptive and antinociceptive events
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Dor
/
Nociceptores
/
Bloqueadores dos Canais de Cálcio
/
Canais de Cálcio
/
Analgésicos Opioides
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2001
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade de São Paulo/BR
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