Interference of propylene glycol with the hole-board test
Braz. j. med. biol. res
;
34(4): 545-7, Apr. 2001. graf
Artigo
em Inglês
| LILACS
| ID: lil-282621
RESUMO
Experimental drugs and/or plant extracts are often dissolved in solvents, including propylene glycol. Nevertheless, there is evidence for psychoactive properties of this alcohol. In this study we found that in the hole-board test 10 percent propylene glycol did not modify the head-dipping behavior. However, 30 percent propylene glycol induced an increase in the number of head-dips (46.92 + or - 2.37 compared to 33.83 + or - 4.39, P<0.05, ANOVA/Student-Newman-Keuls), an effect comparable to that obtained with 0.5 mg/kg diazepam (from 33.83 + or - 4.39 to 54 + or - 3.8, P<0.01, ANOVA/Student-Newman-Keuls). These results demonstrate that 30 percent propylene glycol has significant anxiolytic effects in this model and therefore cannot be used as an innocuous solvent
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Solventes
/
Ansiolíticos
/
Comportamento Animal
/
Propilenoglicol
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2001
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal do Rio Grande do Sul/BR
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