APOE epsilon4 and Alzheimer's disease: positive association in a Colombian clinical series and review of the Latin-American studies
Arq. neuropsiquiatr
;
59(1): 11-17, Mar. 2001. tab
Artigo
em Inglês
| LILACS
| ID: lil-284230
RESUMO
OBJECTIVE:
As the strength of the association between the APOE epsilon4 allele and Alzheimer's disease (AD) varies across ethnic groups, we studied if there was such an association in Colombian patients.METHOD:
We performed apolipoprotein E (APOE) genotyping in a clinical sample of 83 unrelated AD patients, predominantly late-onset (>65 yrs) including familial ( n =30) and sporadic AD cases (n= 53) diagnosed according to NINCDS-ADRDA criteria and assessed by a multi-disciplinary team. Control subjects (n = 44) had no significant cognitive impairment by medical interview and neuro-psychological testing.RESULTS:
We found a high association (OR= 5.1 95 percentCI 1.9 -13.6) between APOE epsilon4 and AD, in this series with predominantly late-onset cases with familial aggregation in 24 cases (28.9 percent). A significant negative association was found between epsilon2 and AD (OR= 0.2 95 percent CI 0.05-0.75).CONCLUSION:
Further population-based surveys in Colombia are warranted to precise a possible dose effect of APOE epsilon4
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Apolipoproteínas E
/
Doença de Alzheimer
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Fatores de risco
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Colômbia
Idioma:
Inglês
Revista:
Arq. neuropsiquiatr
Assunto da revista:
Neurologia
/
Psiquiatria
Ano de publicação:
2001
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Bélgica
/
Colômbia
Instituição/País de afiliação:
Flanders Interuniversity Institute for Biotechnology/BE
/
Instituto Nacional de Salud/CO
/
Universidad Javeriana/CO
/
University of Antwerp/BE
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