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Whipple's disease. Report of five cases with different clinical features
Ferrari, Maria de Lourdes de Abreu; Vilela, Eduardo Garcia; Faria, Luciana Costa; Couto, Claudia Alves; Salgado, Célio Jefferson; Leite, Virgínia Rios; Brasileiro Filho, Geraldo; Bambirra, Eduardo Alves; Mendes, Claudia Maria de Castro; Carvalho, Silas de Castro; Oliveira, Celso Affonso de; Cunha, Aloísio Sales da.
  • Ferrari, Maria de Lourdes de Abreu; Federal University of Minas Gerais. Faculty of Medicine. Department of Medicine. Belo Horizonte. BR
  • Vilela, Eduardo Garcia; Federal University of Minas Gerais. Faculty of Medicine. Belo Horizonte. BR
  • Faria, Luciana Costa; Federal University of Minas Gerais. HC. Belo Horizonte. BR
  • Couto, Claudia Alves; Federal University of Minas Gerais. HC. Belo Horizonte. BR
  • Salgado, Célio Jefferson; Federal University of Minas Gerais. Faculty of Medicine. Belo Horizonte. BR
  • Leite, Virgínia Rios; Federal University of Minas Gerais. Faculty of Medicine. Department of Pathological Anatomy and Legal Medicine. Belo Horizonte. BR
  • Brasileiro Filho, Geraldo; Federal University of Minas Gerais. Faculty of Medicine. Department of Pathological Anatomy and Legal Medicine. Belo Horizonte. BR
  • Bambirra, Eduardo Alves; Federal University of Minas Gerais. Faculty of Medicine. Department of Pathological Anatomy and Legal Medicine. Belo Horizonte. BR
  • Mendes, Claudia Maria de Castro; Federal University of Minas Gerais. University Hospital. Endoscopy Service. Belo Horizonte. BR
  • Carvalho, Silas de Castro; Federal University of Minas Gerais. University Hospital. Endoscopy Service. Belo Horizonte. BR
  • Oliveira, Celso Affonso de; Federal University of Minas Gerais. Faculty of Medicine. Department of Medicine. Belo Horizonte. BR
  • Cunha, Aloísio Sales da; Federal University of Minas Gerais. Faculty of Medicine. Department of Medicine. Belo Horizonte. BR
Rev. Inst. Med. Trop. Säo Paulo ; 43(1): 45-50, Jan.-Feb. 2001. ilus
Artigo em Inglês | LILACS | ID: lil-285680
ABSTRACT
Whipple's disease (WD) is a rare systemic disease of infectious etiology which involves the small intestine but can virtually affect any organ. We present here five cases (four males and one female) ranging in age from 20 to 59 years. All patients had intestinal involvement associated or not with clinical manifestations linked to this organ. Vegetation in the tricuspid valve was observed in one patient, suggesting endocarditis caused by Tropheryma whippelii, with disappearance of the echocardiographic alterations after treatment. In one of the male patients the initial clinical manifestation was serologically negative spondylitis, with no diarrhea occurring at any time during follow-up. Ocular involvement associated with intestinal malabsorption and significant weight loss were observed in one case. In the other two cases, diarrhea was the major clinical manifestation. All patients were diagnosed by histological examination of the jejunal mucosa and, when indicated, of extraintestinal tissues by light and electron microscopy. After antibiotic treatment, full remission of symptoms occurred in all cases. A control examination of the intestinal mucosa performed after twelve months of treatment with sulfamethoxazole-trimethoprim revealed the disappearance of T. whippelii in four patients. The remaining patient was lost to follow-up
Assuntos
Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Doença de Whipple Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Rev. Inst. Med. Trop. Säo Paulo Assunto da revista: Medicina Tropical Ano de publicação: 2001 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Federal University of Minas Gerais/BR

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Doença de Whipple Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Rev. Inst. Med. Trop. Säo Paulo Assunto da revista: Medicina Tropical Ano de publicação: 2001 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Federal University of Minas Gerais/BR