Variants of the Plasmodium vivax circumsporozoite protein (VK210 and VK247) in Colombian isolates
Mem. Inst. Oswaldo Cruz
; 96(5): 709-712, July 2001. mapas, tab
Article
em En
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| ID: lil-289362
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BR1.1
RESUMO
Phenotypic diversity has been described in the central repeated region of the circumsporozoite protein (CSP) from Plasmodium vivax. Two sequences VK210 (common) and VK247 (variant) have been found widely distributed in P. vivax isolates from several malaria endemic areas around the world. A third protein variant called P. vivax-like showing a sequence similar to the simian parasite P. simio-ovale has also been described. Here, using an immunofluorescent test and specific monoclonal antibodies, we assessed the presence of two of these protein variants (VK210 and VK247) in laboratory produced sporozoite. Both sequences were found in parasite isolates coming from different geographic regions of Colombia. Interestingly, sporozoites carrying the VK247 sequence were more frequently produced in Anopheles albimanus than sporozoites with the VK210 sequence. This difference in sporozoites production was statistically significant (p <0.05, Kruskal-Wallis); not correlation was found with parameters as the total number of parasites or gametocytes in blood from human donors used to feed mosquitoes. Previous studies in the same region have shown a higher prevalence of anti-VK210 antibodies which in theory may suggest their role in blocking the development of sporozoites carrying the CSP VK210 sequence
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Índice:
LILACS
Assunto principal:
Plasmodium vivax
/
Variação Genética
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Proteínas de Protozoários
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
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Female
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Humans
País/Região como assunto:
America do sul
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Colombia
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
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PARASITOLOGIA
Ano de publicação:
2001
Tipo de documento:
Article
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Project document