Alteraçoes no teste ultra-rápido da urease e no exame anatomopatológico para Helicobacter pylori induzidas por drogas anti-secretoras / Changes in ultrarapid urease test and histopathological examination for Helicobacter pylori by antisecretory drugs
Arq. gastroenterol
;
38(1): 3-7, Jan.-Mar. 2001. tab
Artigo
em Português
| LILACS
| ID: lil-290411
ABSTRACT
One of the major problems when evaluating dyspeptic patients at public hospitals is the large interval between the consultation and the endoscopy, leading to the prescription of antisecretory drugs, what can be responsible for false results on examinations. AIM:
To evaluate changes in ultrarapid urease test and histopathological examination for Helicobacter pylori by antisecretory drugs.METHODS:
In a prospective double-blind study, 50 patients with dyspeptic complaints and endoscopic diagnosis of peptic ulcer, erosive gastritis, esophagitis or duodenitis, with a positive urease test, were randomized to a 7-day course of treatment with either omeprazole 20 mg or ranitidine 300 mg a day. Before and after treatment, two biopsy specimens each were obtained from the antrum and corpus and an ultrarapid urease test and a histopathological examination for Helicobacter pylori were performed.RESULTS:
There were no significant changes in the results of ultrarapid urease test and histopathological examination for Helicobacter pylori after treatment with ranitidine. With omeprazole, we observed a decrease in positive results in ultrarapid urease test and histopathological examination for Helicobacter pylori in the antrum, but not in the corpus.CONCLUSION:
Omeprazole, used for 7 days, can lead to negative results in ultrarapid urease test and histopathological examination for Helicobacter pylori in the antrum, and should not be employed in patients before the endoscopy is performed.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Urease
/
Helicobacter pylori
/
Infecções por Helicobacter
/
Gastroenteropatias
/
Antagonistas dos Receptores H2 da Histamina
/
Antiulcerosos
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Português
Revista:
Arq. gastroenterol
Assunto da revista:
Gastroenterologia
Ano de publicação:
2001
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de Juiz de Fora/BR
/
Universidade Federal de Säo Paulo/BR
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