The G209A mutation in the alpha-synuclein gene in Brazilian families with Parkinson's disease
Arq. neuropsiquiatr
;
59(3B): 722-724, Sept. 2001. tab
Artigo
em Inglês
| LILACS
| ID: lil-295838
ABSTRACT
A missense G209A mutation of the alpha-synuclein gene was recently described in a large Contursi kindred with Parkinson's disease (PD). The objective of this study is to determine if the mutation G209A of the alpha-synuclein gene was present in 10 Brazilian families with PD. PD patients were recruited from movement disorders clinics of Brazil. A family history with two or more affected in relatives was the inclusion criterion for this study. The alpha-synuclein G209A mutation assay was made using polymerase chain reaction and the restriction enzyme Tsp45I. Ten patients from 10 unrelated families were studied. The mean age of PD onset was 42.7 years old. We did not find the G209A mutation in our 10 families with PD. Our results suggest that alpha-synuclein mutation G209A is uncommon in Brazilian PD families
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Doença de Parkinson
/
Mutação
/
Proteínas do Tecido Nervoso
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Arq. neuropsiquiatr
Assunto da revista:
Neurologia
/
Psiquiatria
Ano de publicação:
2001
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Estados Unidos
Instituição/País de afiliação:
Federal University of Paraná/BR
/
Genetika- Centro de Aconselhamento e Laboratório de Genética/BR
/
Hospital de Base/BR
/
National Institute of Health/US
/
Unicamp/BR
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