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The impact of repeated treatment with praziquantel of schistosomiasis in children under six years of age living in an endemic area for Schistosoma haematobium infection
Mduluza, T; Ndhlovu, P. D; Madziwa, T. M; Midzi, N; Zinyama, R; Turner, C. M. R; Chandiwana, S. K; Nyazema, N; Hagan, P.
  • Mduluza, T; University of Zimbabwe. Department of Biochemistry. Harare. ZW
  • Ndhlovu, P. D; University of Zimbabwe. Department of Biochemistry. Harare. ZW
  • Madziwa, T. M; University of Zimbabwe. Department of Pharmacy. Harare. ZW
  • Midzi, N; Blair Research Institute. Harare. ZW
  • Zinyama, R; Blair Research Institute. Harare. ZW
  • Turner, C. M. R; University of Glasgow. Division of Infection and Immunity. Glasgow. GB
  • Chandiwana, S. K; University of Zimbabwe. Department of Biochemistry. Harare. ZW
  • Nyazema, N; University of Zimbabwe. Department of Pharmacy. Harare. ZW
  • Hagan, P; University of Glasgow. Division of Infection and Immunity. Glasgow. GB
Mem. Inst. Oswaldo Cruz ; 96(suppl): 157-164, Sept. 2001. tab
Artigo em Inglês | LILACS | ID: lil-295894
ABSTRACT
Praziquantel was given every eight weeks for two years to children aged under six years of age, living in a Schistosoma haematobium endemic area. Infection with S. haematobium and haematuria were examined in urine and antibody profiles (IgA, IgE, IgM, IgG1, IgG2, IgG3, and IgG4) against S. haematobium adult worm and egg antigens were determined from sera collected before each treatment. Chemotherapy reduced infection prevalence and mean intensity from 51.8 percent and 110 eggs per 10 ml urine, respectively, before starting re-treatment programme to very low levels thereafter. Praziquantel is not accumulated after periodic administration in children. Immunoglobulin levels change during the course of treatment with a shift towards 'protective' mechanisms. The significant changes noted in some individuals were the drop in 'blocking' IgG2 and IgG4 whereas the 'protecting' IgA and IgG1 levels increased. The antibody profiles in the rest of the children remained generally unchanged throughout the study and no haematuria was observed after the second treatment. The removal of worms before production of large number of eggs, prevented the children from developing morbidity
Assuntos
Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Praziquantel / Esquistossomose Urinária / Anti-Helmínticos Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Animais / Humanos País/Região como assunto: África Idioma: Inglês Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: Medicina Tropical / Parasitologia Ano de publicação: 2001 Tipo de documento: Artigo País de afiliação: Reino Unido / Zimbábue Instituição/País de afiliação: Blair Research Institute/ZW / University of Glasgow/GB / University of Zimbabwe/ZW

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Praziquantel / Esquistossomose Urinária / Anti-Helmínticos Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Animais / Humanos País/Região como assunto: África Idioma: Inglês Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: Medicina Tropical / Parasitologia Ano de publicação: 2001 Tipo de documento: Artigo País de afiliação: Reino Unido / Zimbábue Instituição/País de afiliação: Blair Research Institute/ZW / University of Glasgow/GB / University of Zimbabwe/ZW