Pancreatic involvement in co-infection visceral leishmaniasis and HIV: histological and ultrastructural aspects
Rev. Inst. Med. Trop. Säo Paulo
; 43(2): 75-78, Mar.-Apr. 2001. ilus
Article
em En
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| ID: lil-298579
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RESUMO
The involvement of the gastrointestinal tract in the co-infection of HIV and Leishmania is rarely reported. We report the case of an HIV-infected adult man co-infected with a disseminated form of leishmaniasis involving the liver, lymph nodes, spleen and, as a feature reported for the first time in the English literature, the pancreas. Light microscopy showed amastigote forms of Leishmania in pancreatic macrophages and immunohistochemical staining revealed antigens for Leishmania and also for HIV p24. Microscopic and ultrastructural analysis revealed severe acinar atrophy, decreased zymogen granules in the acinar cytoplasm and also nuclear abnormalities such as pyknosis, hyperchromatism and thickened chromatin. These findings might correspond to the histologic pattern of protein-energy malnutrition in the pancreas as shown in our previous study in pancreas with AIDS and no Leishmania. In this particular case, the protein-energy malnutrition may be due to cirrhosis, or, Leishmania or HIV infection or all mixed. We believe that this case represents the morphologic substratum of the protein energy malnutrition in pancreas induced by the HIV infection. Further studies are needed to elucidate these issues
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LILACS
Assunto principal:
Pâncreas
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Infecções por HIV
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Desnutrição Proteico-Calórica
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Infecções Oportunistas Relacionadas com a AIDS
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Leishmaniose Visceral
Limite:
Adult
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Humans
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Male
Idioma:
En
Revista:
Rev. Inst. Med. Trop. Säo Paulo
Assunto da revista:
MEDICINA TROPICAL
Ano de publicação:
2001
Tipo de documento:
Article