Hepatitis B vaccine in infants: a randomized controlled trial comparing gluteal versus anterolateral thigh muscle administration
Rev. Inst. Med. Trop. Säo Paulo
;
43(3): 139-143, May-June 2001. tab
Artigo
em Inglês
| LILACS
| ID: lil-298903
RESUMO
A significantly diminished antibody response to hepatitis B vaccine has been demonstrated in adults when the buttock is used as the injection site. However, in Brazil, the buttock continues to be recommended as site of injection for intramuscular administration of vaccines in infants. In this age group, there are no controlled studies evaluating the immunogenicity of the hepatitis B vaccine when administered at this site. In the present study, 258 infants were randomized to receive the hepatitis B vaccine either in the buttock (n = 123) or in the anterolateral thigh muscle (n = 135). The immunization schedule consisted of three doses of hepatitis B vaccine (Engerix BFACE="Symbol">â, 10 mug) at 2, 4 and 9 months of age. There were no significant differences in the proportion of seroconversion (99.3 percent x 99.2 percent), or in the geometric mean titer of ELISA anti-HBs (1,862.1 x 1,229.0 mIU/mL) between the two groups. This study demonstrates that a satisfactory serological response can be obtained when the hepatitis B vaccine is administered intramuscularly into the buttock
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Esquemas de Imunização
/
Vacinas contra Hepatite B
/
Injeções Intramusculares
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Humanos
/
Lactente
Idioma:
Inglês
Revista:
Rev. Inst. Med. Trop. Säo Paulo
Assunto da revista:
Medicina Tropical
Ano de publicação:
2001
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Fleury Laboratories/BR
/
Government of Säo Paulo State/BR
/
Universidade Federal de Säo Paulo/BR
/
Universidade de Säo Paulo/BR
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