Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12
Braz. j. med. biol. res
;
34(10): 1237-1245, Oct. 2001. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-299848
ABSTRACT
DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension of 8,123 bp of genomic sequence and encodes a transcript of 1.8 kb that is expressed in all tissues evaluated. The predicted amino acid sequence shows a high similarity to a yeast DEAD-box RNA helicase (Dbp9b) involved in ribosome biogenesis. The new helicase maps to 7p12, a region of frequent chromosome amplifications in glioblastomas involving the epidermal growth factor receptor (EGFR) gene. Nevertheless, co-amplification of DDX26 with EGFR was not detected in nine tumors analyzed
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Cromossomos Humanos Par 7
/
RNA Helicases
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2001
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Reino Unido
Instituição/País de afiliação:
Instituto Ludwig de Pesquisa sobre o Câncer/BR
/
University of Cambridge/GB
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