Prevalencia familiar de patologías metabólicas en paciente con síndrome de ovario poliquístico / Prevalence of metabolic disorders among family members of patients with polycystic ovary syndrome
Rev. méd. Chile
;
129(7): 707-712, jul. 2001. tab
Artigo
em Espanhol
| LILACS
| ID: lil-300034
ABSTRACT
Background:
About 60 percent of patients with polycystic ovary syndrome (PCOS) have insulin resistance, predisposing them to the premature coronary disease and type 2 -diabetes mellitus. However, the history of metabolic disorders in family members of patients with PCOS has been seldom documented in the literature.Aim:
To evaluate the family profile of metabolic disorders of PCOS patients and to determine their relative risk of developing one of them in comparison to a control group. Patients andMethods:
Sixty PCOS patients were evaluated. The control group were 60 normal women. The data were obtained from the clinical history and personal interview with the patients, the controls and their relatives (brothers, parents and grandparents). The metabolic disorders considered were dyslipidemia, obesity, hypertension and diabetes.Results:
The ages were similar between groups (PCOS 24.0 ñ 6.3; control group 24.8 ñ 6.2 years). The prevalence of metabolic disorders was 62 percent in the relatives of the PCOS patients and 27.8 percent in the relatives of the control group (p <0.005). The probability to develop a metabolic disorder within the family was 2.7 (2.2-3.3) fold higher in the PCOS group compared to the control group. The risk of developing hypertension, dyslipidemia, obesity and diabetes was 2.1 (1.5-2.9); 1.8 (1.5-2.7); 3.6 (2.6-4.9) and 2.7 (1.8-3.9), respectively, in the PCOS group compared to the control group.Conclusions:
The probability of finding a metabolic disorder in the families of PCOS patients, is 2.7 fold higher than in the control group families. The metabolic disorders are more frequent in parents and grandparents of the PCOS patients than in those of normal women
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Síndrome do Ovário Policístico
/
Diabetes Mellitus Tipo 2
/
Hiperlipidemias
/
Hipertensão
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
/
Estudo de rastreamento
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2001
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
Instituição/País de afiliação:
Universidad de Chile/CL
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