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Tendencias en la etiología de la meningitis bacteriana aguda en niños chilenos período 1989-1998: impacto de la vacuna anti-H influenzae tipo b Hib / Etiology of acute bacterial meningitis in chilean children from 1989 to 1998: impact of anti H influenzae type b vaccine
Díaz P., José Manuel; Catalán N., Lía; Urrutia L., María Teresa; Prado Jiménez, Valeria; Ledermann Dehnhardt, Walter; Mendoza N., Carmen; Topelberg Volosky, Santiago.
  • Díaz P., José Manuel; s.af
  • Catalán N., Lía; s.af
  • Urrutia L., María Teresa; s.af
  • Prado Jiménez, Valeria; Universidad de Chile. Facultad de Medicina. ICBM. CL
  • Ledermann Dehnhardt, Walter; Universidad de Chile. Facultad de Medicina. ICBM. CL
  • Mendoza N., Carmen; Universidad de Chile. Facultad de Medicina. ICBM. CL
  • Topelberg Volosky, Santiago; Universidad de Chile. Facultad de Medicina. ICBM. CL
Rev. méd. Chile ; 129(7): 719-726, jul. 2001. tab, graf
Artigo em Espanhol | LILACS | ID: lil-300036
ABSTRACT

Background:

Acute bacterial meningitis still has a high mortality and rate of complications.

Aim:

To assess the impact of anti H influenzae vaccination on the epidemiology of acute bacterial meningitis in Chilean children. Material and

methods:

A retrospective study of hospital discharge records of patients with acute bacterial meningitis. Causative agents were studied globally, by hospital and by age group. The changes in etiology from 1989 to 1995 were also assessed. Between 1996 and 1998, only those patients with acute bacterial meningitis caused by H influenzae were recollected.

Results:

In the period prior to vaccination (1989-1995), 1000 cases were registered. The main causative agents were N meningitidis in 33.8 percent, H influenzas type b in 21.9 percent and S pneumoniae in 15.4 percent. The incidence of H influenzae decreased in the period from 36.4 to 9.9 percent (p<0.001) and the incidence of N meningitidis increased from 22.9 to 52.1 percent (p <0.001). The incidence of S pneumoniae did not change significantly. H influenzae predominated in children between 4 and 24 months of age and N meningitidis predominated in children over 25 months of age. In the period after the introduction of vaccination (1995-1998), there was a further decrease in the incidence of H influenzae from 10 to 2 percent (p <0.001). Until 1997, there was a considerable increase in the incidence of N meningitidis, specially in children over 25 months of age. It declined in 1998 to 38 percent.

Conclusions:

There was a reduction in the incidence of acute bacterial meningitis caused by H influenzae prior to the introduction of the vaccine against H influenzae type b. The decrease was more pronounced after the introduction of the vaccine
Assuntos
Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Haemophilus influenzae / Meningites Bacterianas / Vacinas Anti-Haemophilus Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adolescente / Adulto / Criança, pré-escolar / Feminino / Humanos / Lactente / Masculino / Recém-Nascido País/Região como assunto: América do Sul / Chile Idioma: Espanhol Revista: Rev. méd. Chile Assunto da revista: Medicina Ano de publicação: 2001 Tipo de documento: Artigo País de afiliação: Chile Instituição/País de afiliação: Universidad de Chile/CL

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Haemophilus influenzae / Meningites Bacterianas / Vacinas Anti-Haemophilus Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adolescente / Adulto / Criança, pré-escolar / Feminino / Humanos / Lactente / Masculino / Recém-Nascido País/Região como assunto: América do Sul / Chile Idioma: Espanhol Revista: Rev. méd. Chile Assunto da revista: Medicina Ano de publicação: 2001 Tipo de documento: Artigo País de afiliação: Chile Instituição/País de afiliação: Universidad de Chile/CL