Utilizaçäo do abciximab associado à angioplastia primária no tratamento do infarto agudo do miocárdio / The use of abciximab associated with primary angioplasty for treating acute myocardial infarction
Arq. bras. cardiol
;
78(1): 90-105, Jan. 2002. graf, tab
Artigo
em Português, Inglês
| LILACS
| ID: lil-301421
ABSTRACT
OBJECTIVE:
To assess the benefit resulting from the use of abciximab associated with primary angioplasty. The following parameters were analyzed in-hospital, at 30 days, and 6 months (a) flow in the culprit artery; (b) ventricular function; (c) combined outcome of death, acute myocardial infarction, and aditional revascularization.METHODS:
From November 1997 to June 1999, a longitudinal nonrandomized study with historical data of 137 patients with acute myocardial infarction within the first 12 hours. Patients undergoing primary angioplasty and were divided into 2 groups those receiving (A) abciximab (26) or (B) conventional therapy (111). TIMI flow and regional ventricular function estimated by the standard deviation (SD)/chordis index were analyzed.RESULTS:
At the end of angioplasty, TIMI 3 flow was observed in 76.9 percent and 83.8 percent of the patients in groups A and B, respectively (P=0.58). In the reevaluation, patients with TIMI flow <3 showed a 100 percent improvement in group A and a 33 percent in group B (P<0.0001). A significant improvement (P<0.0001) in regional ventricular function, by SD/chordis index, occurred in each group; no significant difference between groups however, was observed (29.9 percent x 20.2 percent; P=0.58). A nonsignificant reduction in the combined outcome in the in-hospital phase (3.85 percent A x 9.0 percent B; P=0.34) and on the 30th day (4.0 percent x 12.0 percent; P=0.22) was observed in group A.CONCLUSION:
Abciximab improved blood flow. Primary angioplasty improved regional ventricular function independent of antithrombotic therapy. Abciximab showed a trend toward reducing the combined outcome in the in-hospital phase and on the 30th day
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Inibidores da Agregação Plaquetária
/
Angioplastia
/
Anticorpos Monoclonais
/
Infarto do Miocárdio
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
/
Português
Revista:
Arq. bras. cardiol
Assunto da revista:
Cardiologia
Ano de publicação:
2002
Tipo de documento:
Artigo
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