Preoperative serum levels of ca 72-4, cea, ca 19-9, and Alpha-fetoprotein in patients with gastric cancer
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
;
57(3): 89-92, May-June 2002.
Artigo
em Inglês
| LILACS
| ID: lil-314469
ABSTRACT
INTRODUCTION:
The clinical importance of preoperative serum levels of CA 72-4, carcinoembryonic antigen (CEA), CA 19-9, and alpha-fetoprotein (AFP) was prospectively evaluated in 44 patients with gastric cancer.METHOD:
The serum tumor marker levels were determined by commercial radioimmunoassay kits. Positivity for CA 72-4 (>4 U/mL), CEA (>5 ng/mL), CA 19-9 (>37 U/mL), and AFP (>10 ng/mL) were correlated according to the stage, histology, and lymph node metastasis. RESULTS ANDDISCUSSION:
CA 72-4 showed a higher positivity rate for gastric cancer (47.7 percent) than CEA (25 percent), CA 19-9 (25 percent), and AFP (0 percent). The combination of CA 72-4 with CEA and CA 19-9 increased the sensitivity to 61.4 percent. The positivity rates of CA 72-4 in patients at stages I and II (initial disease) and in patients at stages III and IV (advanced disease) were 9 percent and 60.6 percent, respectively (P < 0.005). No correlation was found between CEA and CA 19-9 levels and the stage of gastric cancer. There was a tendency of positivity for CA 72-4 to suggest lymph node involvement, but it was not significant (P = 0.075). Serum levels of tumor markers did not show a correlation with the histological types of gastric cancer.CONCLUSION:
Preoperative serum levels of CA 72-4 provided a predictive value in indicating advanced gastric cancer
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Neoplasias Gástricas
/
Biomarcadores Tumorais
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
Assunto da revista:
Medicina
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
University of Säo Paulo/BR
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