Regional mild hypothermia in the protection of the ischemic brain
Acta cir. bras
; 17(4): 232-235, jul.-ago. 2002. tab
Article
em En
| LILACS
| ID: lil-316592
Biblioteca responsável:
BR1.2
RESUMO
Objective:
To demonstrate that mild hypothermia can be a protective element when an ischemic onset occurs in rabbit brains.Methods:
A rabbit model of focal ischemia was used to test the protection provided by mild hypothermia regionally produced by means of the placement of ice bag on the scalp of a hemicranium which has had previously its bone removed. Twenty New Zealand White rabbits were divided into two groups as follows (A) a control group where an ischemic lesion was produced by coagulation of the middle cerebral artery and (B) a brain protected group where mild hypothermia was provided during 80 to 100 minutes after the same ischemic lesion. The brains slices were stained with 2,3,5-Triphenyletrazolium (TTC). The sections were photographed with a digital camera and the infarct volume was measured through a computer program.Results:
The average of infarct volume was 70.53 mm3 in the control group. In the protected group, the average of infarct volume was 41,30 mm3 only in five animals. Five animals of this group did not demonstrate macroscopically and microscopically infarct area.Conclusions:
We concluded that mild hypothermia regionally produced may protect ischemic brains of rabbits.
Texto completo:
1
Índice:
LILACS
Assunto principal:
Isquemia Encefálica
/
Fatores de Proteção
/
Hipotermia Induzida
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2002
Tipo de documento:
Article