Triple therapy with clarithromycin, amoxicillin and omeprazole for Helicobacter pylori eradication in children and adolescents
Arq. gastroenterol
; 38(3): 203-206, jul.-set. 2001.
Article
em En
| LILACS
| ID: lil-317318
Biblioteca responsável:
BR1.1
ABSTRACT
BACKGROUND:
Helicobacter pylori infection presents high prevalence in developing countries, but there are few pediatric assays evaluating antimicrobial treatment.OBJECTIVE:
The aim of this study was to investigate Helicobacter pylori eradication rate using a short regimen (7 and 10 days) of triple therapy with clarithromycin, amoxicillin and omeprazole. PATIENTS ANDMETHODS:
Twenty-five Hp positive patients who presented severe epigastralgia, were submitted to antimicrobial treatment with amoxicillin (50 mg/kg/day--maximum dose 1 g bid), clarithromycin (30 mg/kg/day--maximum dose 500 mg bid) and omeprazole (0.6 mg/kg/day--maximum dose 20 mg bid) during 7 or 10 days. After 2 months, clinical symptoms were evaluated and gastric biopsies were taken to test Hp eradication.RESULTS:
Overall eradication rate was achieved in 16/25 patients (64%--IC(95% = 45-83%), in 11/15 (73%--IC(95%) = 51-95%) patients who used 10 days therapy course and in 5/10 (50%--IC(95%) = 19-81%) who used 7 days therapy course. Eradication drugs were well accepted and adverse effects were reported in two patients (8%).CONCLUSIONS:
This triple therapy regimen had moderate efficacy (64%). The data suggests that 10 days therapy course achieves better eradication rate (73%) than 7 days course (50%) to treat Hp infection in our population
Texto completo:
1
Índice:
LILACS
Assunto principal:
Omeprazol
/
Helicobacter pylori
/
Infecções por Helicobacter
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Claritromicina
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Amoxicilina
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
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Child
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Child, preschool
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Arq. gastroenterol
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2001
Tipo de documento:
Article