Neurohypophyseal hormones and atrial natriuretic peptide in the control of body fluid homeostasis
ARBS annu. rev. biomed. sci
; 3: 5-47, 2001. graf
Article
em En
| LILACS
| ID: lil-318756
Biblioteca responsável:
BR33.1
ABSTRACT
Mammals control the volume and osmolality of their body fluids by stimuli that arise from both the intracellular and extracellular fluid compartments. These stimuli are sensed by two kinds of receptors osmoreceptor-Na+-receptors (plasma osmolality or sodium concentration) and volume or pressure receptors. This information is conveyed to specific areas of the central nervous system responsible for an integrative response, which depends on the integrity of the anteroventral region of the third ventricle, e.g. organum vasculosum of the lamina terminalis, median preoptic nucleus, and subfornical organ. In addition, the paraventricular, supraoptic and suprachiasmatic nuclei are also important structures involved in hydromineral balance. The hypothalamo-neurohypophyseal system plays a fundamental role in the maintenance of body fluid homeostasis by secreting vasopressin and oxytocin in response to osmotic and non-osmotic stimuli. The natriuretic factor in the heart, which is released by the distension of the atria, leading to natriuresis and a myorelaxing action on vascular smooth muscle, also contributes to the hydromineral balance. In addition to the natriuretic factor in the heart, the identification of a natriuretic factor in the central nervous system mediating natriuresis was also demonstrated by purification of hypothalamic extracts. Therefore, the presence of the natriuretic factor in the heart and in the central nervous system allowed the characterization of a neuroendocrine system controlling body fluid homeostasis.
Texto completo:
1
Índice:
LILACS
Assunto principal:
Peptídeos
/
Fator Natriurético Atrial
/
Receptores do Fator Natriurético Atrial
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Pressão Arterial
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Homeostase
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Sistema Hipotálamo-Hipofisário
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
ARBS annu. rev. biomed. sci
Assunto da revista:
BIOLOGIA
Ano de publicação:
2001
Tipo de documento:
Article