Efeito do enalaprilato na cardiotoxidade induzida pela doxorubicina / Effect of enalaprilat on cardiotoxicity induced by doxorubicin
Arq. bras. cardiol
;
67(4): 237-241, Out. 1996.
Artigo
em Português
| LILACS
| ID: lil-319250
ABSTRACT
PURPOSE:
To evaluate whether the enalaprilat, an angiotensin converting enzyme inhibitor, was able to prevent the myocardial damage induced by doxorubicin (DOX).METHODS:
Four groups composed of 10 Wistar rats each were followed for seven weeks control (CONT); treated with enalaprilat (ENA, 1mg/kg/d/sc) treated with doxorubicin (DOX, 25 mg/kg/d/sc), and treated with doxorubicin plus enalaprilat (DOX+ENA). In eight animals of each group, the left ventricle (LV) was prepared for morphometric study and stained with HE and picro-sírius for identifying muscle fibers and collagen. In each group three fragments of the LV were examined with electronic microscopy (EM). For statisticalanalysis:
the one-way analysis of variance was performed and was followed by multiple comparisons test when the difference between groups were detected p values < or = 0.05 were considered significant.RESULTS:
Light microscopy-it was not found any significant difference among the groups for muscle fibers patterns and proportion of collagen fibers of left ventricle. Electronic microscopy-the cristolysis index (proportion between normal and damage mitochondria) demonstrated significant difference between DOX and DOX+ENA groups (30.1 vs 11.6, p < or = 0.01).CONCLUSION:
ENA prevented cardiotoxic alterations induced by DOX minimizing the aggression to the mitochondria and these findings, if confirmed in anima nobilis, may open a new clinical use for this type of drug.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Inibidores da Enzima Conversora de Angiotensina
/
Doxorrubicina
/
Enalaprilato
/
Cardiomiopatias
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Português
Revista:
Arq. bras. cardiol
Assunto da revista:
Cardiologia
Ano de publicação:
1996
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Escola Paulista de Medicina (UNIFESP)/BR
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