Stress-induced expression of the c-fos proto-oncogene in the hippocampal formation
Braz. j. med. biol. res
; 27(4): 1083-1088, Apr. 1994.
Article
em En
| LILACS
| ID: lil-319823
Biblioteca responsável:
BR1.1
ABSTRACT
To investigate the effects of stress on c-fos mRNA expression, rats were submitted to forced immobilization for 15, 30, 60 or 120 min before sacrifice. In situ hybridization was performed on sections containing the dorsal hippocampus with a 32P-labelled 50-base oligonucleotide probe (10(7)-10(9) cpm/micrograms) complementary to nucleotides 370-319 of rat c-fos. Forced restraint induced a time-dependent increase in c-fos mRNA expression which was most pronounced in the dentate gyrus and CA1-CA3 regions of the hippocampal formation, and which peaked after 30 min of immobilization (72.7 +/- 1.0 vs 24.1 +/- 0.8 cpm/mm2 in unrestrained animals). A positive but weaker signal was also detected in the amygdala, pyriform cortex and other parts of the cerebral cortex and habenulae. These results suggest that the hippocampal formation is activated during stress.
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Índice:
LILACS
Assunto principal:
Estresse Fisiológico
/
Proteínas Proto-Oncogênicas c-fos
/
Hipocampo
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1994
Tipo de documento:
Article