Dried blood spots collected on filter paper: an international resource for the diagnosis and genetic characterization of human immunodeficiency virus type-1
Mem. Inst. Oswaldo Cruz
;
91(3): 351-358, May-Jun. 1996.
Artigo
em Inglês
| LILACS
| ID: lil-319863
RESUMO
The collection of dried blood spots (DBS) on filter paper provides a powerful approach for the development of large-scale, population-based screening programs. DBS methods are particularly valuable in developing countries and isolated rural regions where resources are limited. Large numbers of field specimens can be economically collected and shipped to centralized reference laboratories for genetic and (or) serological analysis. Alternatively, the dried blood can be stored and used as an archival resource to rapidly establish the frequency and distribution of newly recognized mutations, confirm patient identity or track the origins and emergence of newly identified pathogens. In this report, we describe how PCR-based technologies are beginning to interface with international screening programmes for the diagnosis and genetic characterization of human immunodeficiency virus type 1 (HIV-1). In particular, we review recent progress using DBS specimens to resolve the HIV-1 infection status of neonates, monitor the genetic evolution of HIV-1 during early infancy and establish a sentinel surveillance system for the systematic monitoring of HIV-1 genetic variation in Asia.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Papel
/
Sorodiagnóstico da AIDS
/
Coleta de Amostras Sanguíneas
/
Síndrome da Imunodeficiência Adquirida
/
HIV-1
/
Filtração
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
/
Lactente
/
Recém-Nascido
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
1996
Tipo de documento:
Artigo
País de afiliação:
Bahamas
/
Canadá
/
Índia
/
Estados Unidos
Instituição/País de afiliação:
AIDS. Saint Paul's Hospital+CA
/
Center for Disease and Prevention/US
/
Centers for Disease Control and Prevention/US
/
Christian Medical College Hospital/IN
/
Hospital Sainte-Justine/CA
/
Princess Margaret Hospital/BS
/
University of British Columbia/CA
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