Salvado de trigo y cáncer de mama: revisitando la hipótesis del estrógeno / Wheat bran and breast cancer: revisiting the estrogen hypothesis
Arch. latinoam. nutr
;
49(4): 309-317, Dec. 1999.
Artigo
em Espanhol
| LILACS
| ID: lil-320285
ABSTRACT
Breast cancer is the most relevant form of cancer among women in Latin America. Many studies have evaluated the hormonal mechanisms involved in mammary carcinogenesis, although new focus is aimed towards factors that can potentially be used individually to reduce risk. Wheat bran seems to show a consistent protective effect in mammary carcinogenesis. Wheat bran, besides high level of insoluble fiber, also contains phytic acid and lignins, phytochemicals that have shown to inhibit in vitro and in vivo growth of mammary cancer. The protective effect of wheat bran in breast carcinogenesis is greatest at the promotional phase and when supplemented to a high fat diet. Doses of wheat bran in the 9-12range have been consistently protective and the inconsistencies observed at higher doses may be dependent on the animal model used. This review examines the protective role of wheat bran in the development of breast cancer and the possible mechanisms involved.
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Índice:
LILACS (Américas)
Assunto principal:
Triticum
/
Neoplasias da Mama
/
Fibras na Dieta
/
Estrogênios
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Animais
/
Feminino
/
Humanos
Idioma:
Espanhol
Revista:
Arch. latinoam. nutr
Assunto da revista:
Bioqu¡mica
/
EducaÆo Alimentar e Nutricional
/
Fenmenos Fisiol¢gicos da NutriÆo
/
Microbiologia de Alimentos
/
NUTRICAO
Ano de publicação:
1999
Tipo de documento:
Artigo
País de afiliação:
Canadá
Instituição/País de afiliação:
University of Toronto/CA
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