Reduced schedule of human anti-rabies immunization with Fuenzalida & Palacios vaccine. Additional data
Rev. Inst. Med. Trop. Säo Paulo
;
35(3): 281-284, May-Jun. 1993.
Artigo
em Inglês
| LILACS, SES-SP
| ID: lil-320585
ABSTRACT
It was reevaluated a reduced schedule for anti-rabies post-exposure immunization with newborn mice nervous tissue vaccine (Fuenzalida & Palacios) in a group of 30 non exposed volunteers. The vaccine was administered by intramuscular injections on days zero, 2, 4, 16 and 27, in the deltoid area. Antibody levels were determinated by a simplified serum neutralization microtest on days zero, 16 and 37. On days 16 and 37 the antibody levels of the whole group was > or = 0.5 IU/ml and > or = 1.0 IU/ml, respectively. The cell mediated immunity was precociously detected (on day 4) by the delayed type hypersensitivity skin test. Our results show that this reduced schedule elicited an early and effective humoral and cellular immune response. However it is necessary other studies with larger groups of vaccinees in order to obtain definitive conclusion.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Raiva
/
Vacina Antirrábica
/
Esquemas de Imunização
Limite:
Adolescente
/
Adulto
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. Inst. Med. Trop. Säo Paulo
Ano de publicação:
1993
Tipo de documento:
Artigo
Instituição/País de afiliação:
Instituto Pasteur de São Paulo/BR
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