Termoestabilidade da vacina contra a raiva, tipo Fuenzalida & Palacios, uso humano / Thermostability of rabies vaccine, type Fuenzalida & Palacios, for human use
Rev. Inst. Med. Trop. Säo Paulo
;
34(1): 27-31, Jan.-Feb. 1992.
Artigo
em Português
| LILACS
| ID: lil-320634
RESUMO
Ten lots of Fuenzalida & Palacios type antirabies vaccine for human use, produced at the Instituto Butantan (São Paulo, Brazil) were stored at temperatures of 45, 37, 28 and 2-8 degrees C. The potency of each lot was determined in samples taken at varied time intervals using the NIH method and lots presenting antigenic values > or = 0,3 were considered satisfactory for use. After 2 hours at 45 degrees C the antigenic value of one out of 10 lots tested was found to be less than the minimum required value. At 37 degrees C all lots maintained satisfactory antigenic values until the third day of storage, whilst at 28 and 2-8 degrees C the potency was fully maintained, respectively for 10 and 360 days. At the ideal temperature of 2-8 degrees C, 100 of the tested vaccines maintained the minimum required antigenicity for a longer period (16 months) than the expiration time of 6-12 months usually recommended for this type of biological produced in Latin American and Caribbean countries. Thus, the obtained data suggested that in countries still producing Fuenzalida & Palacios type vaccine, the expiration tim could be extended to 16 months, what could prevent the unnecessary discarding of products still in useful condition.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Vacina Antirrábica
Limite:
Humanos
Idioma:
Português
Revista:
Rev. Inst. Med. Trop. Säo Paulo
Assunto da revista:
Medicina Tropical
Ano de publicação:
1992
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Instituto Butantan/BR
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