Detection of Toxoplasma gondii soluble antigen, SAG-1(p30), antibody and immune complex in the cerebrospinal fluid of HIV positive or negative individuals
Rev. Inst. Med. Trop. Säo Paulo
;
41(6): 329-338, Nov.-Dec. 1999.
Artigo
em Inglês
| LILACS
| ID: lil-320658
ABSTRACT
Active infection by T. gondii was evaluated by immunoassay for soluble SAG-1 (p30), the major surface antigen from T. gondii, specific antibodies and immune complexes in human cerebrospinal fluid (CSF) samples. A total of 263 samples of CSF were collected from hospitalized patients presenting neurological disorders and analyzed for antibodies to HIV. Patients were divided into two groups HIV positive (n = 96) or HIV negative (n =167). The results of the assays showed that 45 of all samples were positive for soluble SAG-1. Toxoplasma Ag/Ab immune complexes were detected in 19 of the CSF samples and 62 were positive for T. gondii- specific IgG. A combination of these assays in the presence of clinical findings consistent with active Toxoplasma infection may predict the presence of toxoplasmic encephalitis. Moreover, detection of soluble SAG-1 in the CSF of these individuals appears consistent with active infection.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Toxoplasma
/
Imunoglobulina G
/
Anticorpos Antiprotozoários
/
Infecções por HIV
/
Proteínas de Protozoários
/
Complexo Antígeno-Anticorpo
/
Antígenos de Protozoários
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Rev. Inst. Med. Trop. Säo Paulo
Assunto da revista:
Medicina Tropical
Ano de publicação:
1999
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Estados Unidos
Instituição/País de afiliação:
Dartmouth Medical School/US
/
Universidade Federal de Uberlandia/BR
/
Universidade Federal de Uberlândia/BR
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