Vasopressin in the nucleus tractus solitarius: a modulator of baroreceptor reflex control of heart rate
Braz. j. med. biol. res
;
27(4): 1017-1032, Apr. 1994.
Artigo
em Inglês
| LILACS
| ID: lil-321741
RESUMO
1. The main role of the nucleus tractus solitarius (NTS) as a relay center for viscerosensory fibers from the periphery and for pathways from modulatory autonomic centers is reviewed on the basis of its anatomical connections and neurotransmitter content. 2. Vasopressin is present in the entire neuroaxis and is of great importance in the control of cardiovascular function. The high endogenous content and receptor density, and the unique organization of vasopressin fibers projecting to the NTS are fundamental features for the modulatory effect exerted by vasopressin at the NTS on the baroreceptor reflex control of heart rate. 3. Vasopressinergic pathways from the paraventricular nucleus of the hypothalamus to the NTS constitute a physiological mechanism for the tonic maintenance of the baroreflex sensitivity and for displacing the heart rate response to higher values during increased activity, without changing the baroreflex sensitivity. This type of mechanism should play an important role in facilitating the tachycardic response during isotonic exercise.
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Índice:
LILACS (Américas)
Assunto principal:
Vasopressinas
/
Núcleo Solitário
/
Barorreflexo
/
Frequência Cardíaca
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1994
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade de São Paulo/BR
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