Efecto de la vitamina E, DL alfa-tocoferol, sobre el daño cromosómico en linfocitos de pacientes con ataxia telangiectasia / Effect of vitamin E, DL alfa-tocopherol, on chromosomal damage in lymphocytes from patients with ataxia telangiectasia
Rev. méd. Chile
;
130(9): 957-963, sept. 2002. tab
Artigo
em Espanhol
| LILACS
| ID: lil-323228
ABSTRACT
Background:
In ataxia telangiectasia (A-T), the lack of a functional ATM kinase is associated with disturbances in the processing of DNA damage and a chronic oxidative stress. These disturbances may be responsible for an increment of chromosomal damage in A-T cells.Aim:
To study the in vitro effect of vitamin E (DL-a-tocopherol) on the frequency of chromosomal damage of lymphocytes from patients with A-T. Patients andmethods:
Seven patients with A-T and age-sex matched controls were studied. Chromosomal damage in mitosis was evaluated in lymphocytes cultures both under basal conditions and when G2 repair was prevented by 5 mM caffeine.Results:
In cells from patients with A-T, vitamin E induced a 57.1 and 47.9 percent decrease in chromosomal damage under basal and inhibited G2 repair conditions, respectively. However, there was a non significant improvement in their repair activity. Vitamin E effects on chromosomal damage was not significant in control subjects.Conclusions:
Vitamin E reduces chromosomal damage in lymphocytes from patients with ataxia telangiectasia
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Vitamina E
/
Técnicas In Vitro
/
Ataxia Telangiectasia
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2002
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
Instituição/País de afiliação:
Pontificia Universidad Católica de Chile/CL
/
Universidad de Chile/CL
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