Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of Aragua
Genet. mol. biol
;
25(1): 21-34, 2002. tab
Artigo
em Inglês
| LILACS
| ID: lil-324981
ABSTRACT
Seven polymorphic sites in the beta-globin gene cluster were analyzed on a sample of 96 chromosomes of Venezuelan sickle cell patients from the State of Aragua. The Benin haplotype was predominant with a frequency of 0.479, followed by the Bantu haplotype (0.406); a minority of cases with other haplotypes was also identified atypical Bantu A2 (0.042), Senegal (0.031), atypical Bantu A7 (0.021) and Saudi Arabia/Indian (0.021) haplotypes; however, the Cameroon haplotype was not identified in this study. Our results are in agreement with the historical records that establish Sudanese and Bantu origins for the African slaves brought into Venezuela
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Haplótipos
/
Globinas
/
Hemoglobina Falciforme
/
Anemia Falciforme
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
América do Sul
/
Venezuela
Idioma:
Inglês
Revista:
Genet. mol. biol
Assunto da revista:
Genética
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
Venezuela
Instituição/País de afiliação:
Hospital Central de Maracay/VE
/
Universidad Pedagógica Experimental Libertador Maracay/VE
/
Universidad de Carabobo Núcleo Aragua/VE
Similares
MEDLINE
...
LILACS
LIS