Progressive supranuclear palsy in a sample of brazilian population: clinical features of 16 patients
Arq. neuropsiquiatr
;
60(4): 917-922, Dec. 2002. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-326161
RESUMO
Progressive supranuclear palsy (PSP) is an uncommon disorder characterized by marked postural instability, vertical gaze abnormalities and axial rigidity. The purpose of this study is to report the clinical features of 16 consecutive subjects seen over a 10-year period at a Movement Disorders Clinic. These subjects fulfilled criteria for probable PSP namely those of the National Institute of Neurologic Disorders and Stroke (NINDS) and the Society for PSP (SPSP). This patient-group represented 2.1 percent of all degenerative parkinsonians observed and the mean age of onset of the disease was 64.7 years (sd = ± 7.2). Postural instability with falls was the most frequent initial feature presented in PSP patients (62.5 percent). The hallmark of the disease, the supranuclear vertical gaze palsy, appeared after 2.3 years of disease onset, and only 12.5 percent had such manifestation at the first evaluation. Transient tremor was observed with a relatively high frequency in this group (44 percent), but only 19 percent had rest tremor. Chronic dacryocystitis, probably related to a paucity of blinking, was observed in two patients as an inaugural manifestation. In the first evaluation, only 19 percent of the 16 patients were diagnosed as probable PSP. The mean interval prior to the final diagnosis was 2.4 years
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Paralisia Supranuclear Progressiva
Limite:
Aged80
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Arq. neuropsiquiatr
Assunto da revista:
Neurologia
/
Psiquiatria
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Estadual do Oeste do Paraná/BR
/
Universidade de São Paulo/BR
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