La sobredosis de paracetamol y la colestasis experimental inducen la expresión de los genes que codifican la P-glicoprotína tipo 1 en ratas / Paracetamol overdose and experimental cholestasis induced gene expresion that codified P-glicoprotein tipe 1 in rats
Acta gastroenterol. latinoam
;
32(2): 79-82, nov. 2002. ilus, tab
Artigo
em Espanhol
| LILACS
| ID: lil-327727
ABSTRACT
Excretion of lipophilic cationic toxic compounds from the interior of the hepatocyte to the bile is mediated by P-Glycoprotein. It is an integral protein located in the bile canaliculi. The present work study the hepatic expression of P-Glycoprotein in different models of experimental liver disease Acute paracetamol intoxication, extrahepatic cholestasis and cholestasis followed by acute paracetamol intoxication. mRNA was isolated from liver tissue, and the expression of Pg-p was assessed by Northern blot. It is concluded that the hepatic expression of mdr1b is increased in the experimental liver diseases when compared to controls. On the other hand, mdr2 expression was similar between the different groups
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Índice:
LILACS (Américas)
Assunto principal:
Colestase Extra-Hepática
/
Regulação da Expressão Gênica
/
Membro 1 da Subfamília B de Cassetes de Ligação de ATP
/
Analgésicos não Narcóticos
/
Genes MDR
/
Hepatopatias
/
Acetaminofen
Limite:
Animais
Idioma:
Espanhol
Revista:
Acta gastroenterol. latinoam
Assunto da revista:
Gastroenterologia
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
Argentina
Instituição/País de afiliação:
Universidad de Buenos Aires/AR
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