Antibody conjugate radioimmunotherapy of superficial bladder cancer
Braz. arch. biol. technol
;
45(spe): 87-89, Sept. 2002. ilus
Artigo
em Inglês
| LILACS
| ID: lil-329811
ABSTRACT
The administration of antibody conjugates for cancer therapy is now proving to be of clinical value. We are currently undertaking a programme of clinical studies using the monoclonal antibody C595 (IgG3) which reacts with the MUC1 glycoprotein antigen that is aberrantly expressed in a high proportion of bladder tumours. Radioimmunoconjugates of the C595 antibody have been produced with high radiolabelling efficiency and immunoreactivity using Tc-99m and In-111 for diagnostic imaging, and disease staging and the cytotoxic radionuclides Cu-67 and Re-188 for therapy of superficial bladder cancer. A Phase I/II therapeutic trail involving the intravesical administration of antibody directly into the bladder has now begun
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Idioma:
Inglês
Revista:
Braz. arch. biol. technol
Assunto da revista:
Biologia
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
Reino Unido
Instituição/País de afiliação:
University and City Hospitals/GB
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