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Insuficiencia suprarrenal secundaria a paracoccidioidomicosis / Adrenal gland insufficiency secondary to paracoccidioidomycosis
Oñate, José M; Tobón, Angela María; Restrepo, Angela.
  • Oñate, José M; Universidad del Valle. Cali. CO
  • Tobón, Angela María; Corporación para Investigaciones Biológicas. Grupo de Micología Médica. Medellín. CO
  • Restrepo, Angela; Corporación para Investigaciones Biológicas. Grupo de Micología Médica. Medellín. CO
Biomédica (Bogotá) ; 22(3): 280-286, sep. 2002.
Artigo em Espanhol | LILACS | ID: lil-330480
ABSTRACT
Paracoccidioidomycosis is regularly associated with adrenal insufficiency in 10-15 of symptomatic cases, and in some instances, diagnosis of the mycosis precedes the adrenal manifestation. To establish the frequency of this association, records were reviewed of 207 cases diagnosed with mycosis at the Mycology Service of the Corporación para Investigaciones Biológicas. Six cases (2.9) were found to have adrenal insufficiency. Patients were all males with a mean age of 67.2 years (range 48-75) and most worked in agriculture. The duration of the symptoms of adrenal damage was 4.1 months (range 2-6). All patients experienced weight loss and malaise; all had abnormal lung X-rays. Major clinical improvement was recorded after initiation of the specific treatments consisting of itraconazole, prednisolone and fluorcortisone. Diminished antibody titers against Paracoccidioides brasiliensis were also recorded after treatment. Prompt treatment re-established adrenal function and effected recovery of normal gland morphology. Consequently, early detection of hypoadrenalism in patients living in the endemic areas is necessary to avoid further adrenal damage and permits a shorter hormonal treatment period in patients afflicted by the mycosis.
Assuntos
Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Paracoccidioidomicose / Doença de Addison Tipo de estudo: Estudo diagnóstico / Estudo de rastreamento Limite: Feminino / Humanos / Masculino Idioma: Espanhol Revista: Biomédica (Bogotá) Assunto da revista: Medicina Ano de publicação: 2002 Tipo de documento: Artigo País de afiliação: Colômbia Instituição/País de afiliação: Corporación para Investigaciones Biológicas/CO / Universidad del Valle/CO

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Paracoccidioidomicose / Doença de Addison Tipo de estudo: Estudo diagnóstico / Estudo de rastreamento Limite: Feminino / Humanos / Masculino Idioma: Espanhol Revista: Biomédica (Bogotá) Assunto da revista: Medicina Ano de publicação: 2002 Tipo de documento: Artigo País de afiliação: Colômbia Instituição/País de afiliação: Corporación para Investigaciones Biológicas/CO / Universidad del Valle/CO