High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals. A comparative approach using historical controls
Mem. Inst. Oswaldo Cruz
;
98(1): 145-149, Jan. 30, 2003. tab
Artigo
em Inglês
| LILACS
| ID: lil-331393
ABSTRACT
We analyzed data from historical controls treated with meglumine antimoniate to compare the frequency of adverse events observed in patients with cutaneous leishmaniasis treated with the same dose of meglumine antimoniate contaminated with heavy metals in an endemic area of the State of Bahia, Brazil. Group A patients were treated in 2000 with the drug produced by Eurofarma Laboratórios Ltda., São Paulo, Brazil (lot A) and group B patients were treated in 1996 with the reference drug produced by Rhodia Farma Ltda., São Paulo, Brazil (lot B). We observed an unusual higher frequency of skin reactions in group A patients. However, all type of adverse events observed in group A were also observed in group B. The physico-chemical analysis of these lots revealed that lot A had lower pH and higher concentration of total and trivalent antimony, lead, cadmium, and arsenic. Our findings suggest that the skin reactions could be attributed to heavy metal contamination of lot A
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Compostos Organometálicos
/
Arsênio
/
Leishmaniose Cutânea
/
Metais Pesados
/
Meglumina
/
Antiprotozoários
Tipo de estudo:
Estudo observacional
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2003
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de Santa Maria/BR
/
Universidade de Brasília/BR
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