Soroprevalência de anticorpos contra o antígeno CagA do Helicobacter pylori em pacientes com úlcera gástrica na regiÒo Norte do Brasil / Seroprevalence of antibodies against Helicobacter pylori CagA antigen in patients with gastric ulcer in the North region of Brazil
Rev. Soc. Bras. Med. Trop
;
35(4): 307-310, jul.-aug. 2002.
Artigo
em Português
| LILACS
| ID: lil-331752
ABSTRACT
Helicobacter pylori is a pathogenic agent with a worldwide distribution and is involved in the development of many gastrointestinal diseases. Nowadays infection with the virulent strain CagA+ of H. pylori is considered one of the main etiological factors in the development of gastric ulcer. Based on this information, we investigated the seroprevalence of virulent strains among patients with gastric ulcer from one region, using serologic tests to detect antibodies against H. pylori and CagA protein. Infection by the virulent strain was found in 82 (40/55) of the patients, and among these, 89 (40/45) presented an increased degree of inflammation in the gastric mucosa, with a dense infiltration of leukocytes in the tissue, which probably favored the formation of gastric ulcer. We concluded that the presence of the virulent strain is related to the development of an increased inflammation in the gastric mucosa.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Úlcera Gástrica
/
Proteínas de Bactérias
/
Helicobacter pylori
/
Anticorpos Antibacterianos
/
Antígenos de Bactérias
Limite:
Adulto
/
Aged80
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Português
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Hospital Ofir Loiola/BR
/
Universidade Federal do Pará/BR
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