Histological evaluation of the lesion induced by inoculation of Leishmania mexicana in the cheek pouch of the hamster
Rev. Soc. Bras. Med. Trop
;
35(4): 293-297, jul.-aug. 2002.
Artigo
em Inglês
| LILACS
| ID: lil-331754
ABSTRACT
We have studied the role of the immune response in the morphology of the leishmaniotic granuloma induced in the cheek pouch of hamsters, an immunologically privileged site, after inoculation of 3 x 10(5) Leishmania mexicana. Animals were histologically and immunologically evaluated until 120 days after inoculation. Independent of the time of sacrifice, the animals were always non-reactors to the footpad test (FPT). At histology, the introduction of L. mexicana in the cheek pouch leads to an abscess that evolves to a granulomatous reaction rich in amastigote forms, and later it leads to resolution, even in the absence of immune response detectable by FPT. Our results demonstrate that the development of immune response is not preponderant for the control of infection induced by L. mexicana inoculated subcutaneously in the cheek pouch of the hamster. It also suggests that the macrophages present in the leishmaniotic granuloma are capable of eliminating this parasite, even in the absence of immune response evaluated by FPT.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Leishmania mexicana
/
Leishmaniose Cutânea
/
Granuloma
Limite:
Animais
País/Região como assunto:
México
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Instituto Lauro de Souza Lima/BR
/
Universidade Estadual Paulista/BR
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