Efficacy of azithromycin in the treatment of cutaneous leishmaniasis
Rev. Soc. Bras. Med. Trop
;
36(1): 65-69, jan.-fev. 2003. tab
Artigo
em Inglês
| LILACS
| ID: lil-332890
ABSTRACT
The present open pilot study was conducted to assess the efficacy of azithromycin for the treatment of patients with cutaneous leishmaniasis in Araçuaí and Varzelândia, MG. Twenty-four patients with less of six months of disease evolution were treated after clinical examination, Montenegro test and a biopsy. The treatment schemes consisted of oral doses of 500 mg per day for 3, 5 and 10 days and of 1000 mg for two days. A clinical control was performed monthly and treatment cycles were repeated when necessary until full reepithelialization of the lesions. On the occasion of the final evaluation, 20 patients had completed the study and 17 of them (85 percent) were cured. The time to obtain a cure was 60 days ifor 6 (30 percent) patients, 90 days for 7 (35 percent), and 120 for 4 (20 percent). The three patients with treatment failure received a pentavalent antimonial for 20 days. No adverse reactions to the medication were observed and a 14 month follow-up did not show recurrence in any patient. These results suggest that azithromycin can be a good therapeutic option for the treatment of cutaneous leishmaniasis caused by Leishmania Viannia brasiliensis
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Leishmaniose Cutânea
/
Azitromicina
/
Antibacterianos
Tipo de estudo:
Estudos de avaliação
/
Estudo observacional
/
Estudo prognóstico
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
2003
Tipo de documento:
Artigo
País de afiliação:
Argentina
/
Brasil
Instituição/País de afiliação:
Faculdade de Medicina do Triângulo Mineiro/BR
/
Fundacion Huesped/AR
/
Ministério da Saúde/BR
/
Municipal Polyclinic of Araçuaí/BR
/
Universidade Federal de Uberlândia/BR
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