In vitro antimicrobial susceptibility in clinical isolates of Enterococcus species
Salud pública Méx
;
45(2): 96-101, mar.-abr. 2003. tab
Artigo
em Inglês
| LILACS
| ID: lil-333552
RESUMO
OBJECTIVE:
To describe the antimicrobial activity of several antimicrobial agents against 97 clinical significant isolates of Enterococcus spp. MATHERIAL ANDMETHODS:
During a 2-year prospective study at Instituto Nacional de Pediatria (National Institute of Pediatrics) in Mexico City. Ninety seven strains of Enterococcus spp. (60 E. faecalis and 37 E. faecium) were tested against 11 antibiotics. Susceptibility tests were performed with agar, according to the standards of the sNational Committee for Clinical Laboratory Standards (NCCLS). Isolates were screened for high-level resistance (HLR) to beta-lactams, aminoglycosides, glycopeptides and other antibiotics, as well as for vancomycin-phenotypes. Differences between proportions were evaluated with chi2 of Fisher exact fest.RESULTS:
Overall resistance rates to the antibiotics tested were 17/97 (17.5 percent) to penicillin, ampicillin, amoxicillin-clavulanate and imipenem. There was neither HLR nor beta-lactamase production; 74/97 (48.4 percent) were resistant to erythromycin; 60 percent to ciprofloxacin; 31/97 (32 percent) to gentamicin, and 55/97 (56.7 percent) to streptomycin. Seven strains were vancomycin-resistant enterococci (VRE), all of them identified as E. faecium; 5/7 with Van A and 2/7 with Van B phenotypes. All the isolates were susceptible to linezolid. The difference in susceptibility among species was significant.CONCLUSIONS:
Mutidrug-resistant enterococci is a real problem and continuous surveillance is necessary. The microbiology laboratory is the first line of defense against the spread of multiantibiotic-resistan enterococci in the hospital environment . All the strains recovered should be tested for susceptibility to ampicillin, streptomycin, gentamicin and glycopeptides
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Testes de Sensibilidade Microbiana
/
Enterococcus
/
Antibacterianos
Tipo de estudo:
Guia de Prática Clínica
/
Estudo observacional
Limite:
Humanos
Idioma:
Inglês
Revista:
Salud pública Méx
Assunto da revista:
Saúde Pública
Ano de publicação:
2003
Tipo de documento:
Artigo
País de afiliação:
México
Instituição/País de afiliação:
Hospital Infantil de México Federico Gómez/MX
/
Instituto Nacional de Pediatría/MX
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