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CCR5 and beta-chemokines in HIV-1 infected children
Sanchez-Carrasquillo, Edwin; García, Vivian; Rivera, Cynthia E; Febo, Irma; Melendez-Guerrero, Loyda M.
  • Sanchez-Carrasquillo, Edwin; University of Puerto Rico. Medical Sciences Campus. Department of Microbiology and Medical Zoology. San Juan. PR
  • García, Vivian; University of Puerto Rico. Medical Sciences Campus. Department of Microbiology and Medical Zoology. San Juan. PR
  • Rivera, Cynthia E; Pediatric Hospital. Gamma Project. San Juan. PR
  • Febo, Irma; RCMI Clinical Research Center. PR
  • Melendez-Guerrero, Loyda M; University of Puerto Rico. Medical Sciences Campus. Department of Microbiology and Medical Zoology. San Juan. PR
P. R. health sci. j ; 19(4): 345-351, Dec. 2000.
Artigo em Inglês | LILACS | ID: lil-334082
RESUMO
The duration from initial infection with HIV-1 to CD4 lymphocyte depletion and progression to AIDS varies among infected individuals. Despite treatment with highly active antiretroviral therapy (HAART), patients still show different stages of disease progression. We examined the role of beta-chemokines and its receptor, CCR5 in HIV-1 infected children in order to define determinants of HIV progression among treated individuals. Population was divided in two groups Group 1--Long Term Non Progressors (LTNP) includes 10 patients with B1-B2 CDC disease classification and with a less aggressive therapy (only 2 in HAART); Group 2--Rapid Progressors (RP) includes 9 patients with C3 disease classification. All the patients had a CCR5 wild type (wt) genotype indicating that they do not have the 32 base-pair deletion associated with slower progression. There was an increased production of MIP 1-beta in 8/10 LTNP but only in 4/9 Progressors (Paired t-test/Wilcoxon Sign test, p-value < 0.05). The change in the levels of MIP-1 beta after PHA stimulation was statistically significant in both groups. The levels of RANTES increased in LTNP and RP and the change of the levels after mitogen stimulation was statistically significant for both groups included. The production of RANTES and MIP-1 beta in response to stimulation between both groups was not statistically significant. The production of MIP-1 alpha was variable in both groups and the difference in the levels after mitogen stimulation between the groups was not statistically significant. These results suggest that beta-chemokines do not play an important role in HIV-1 progression in children undergoing HAART.
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Índice: LILACS (Américas) Assunto principal: Infecções por HIV / Receptores CCR5 / Quimiocinas CC Limite: Criança / Humanos Idioma: Inglês Revista: P. R. health sci. j Assunto da revista: Medicina Ano de publicação: 2000 Tipo de documento: Artigo País de afiliação: Portugal / Porto Rico Instituição/País de afiliação: Pediatric Hospital/PR / RCMI Clinical Research Center/PR / University of Puerto Rico/PR

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Índice: LILACS (Américas) Assunto principal: Infecções por HIV / Receptores CCR5 / Quimiocinas CC Limite: Criança / Humanos Idioma: Inglês Revista: P. R. health sci. j Assunto da revista: Medicina Ano de publicação: 2000 Tipo de documento: Artigo País de afiliação: Portugal / Porto Rico Instituição/País de afiliação: Pediatric Hospital/PR / RCMI Clinical Research Center/PR / University of Puerto Rico/PR